October 2011-- During the next six months, The Canary Report will be dedicated solely to me sharing my experiences while on the Gupta Amygdala Retraining program for MCS. If you'd like to be notified by email when blog entries are made, please subscribe in the right hand column below. During the entire six months, this blog will remain online but Our Canary Report network and forum will be offline and inaccessible to our members. Thank you for all your support! Aloha, Susie
 

Who knew that only six days into Ashok Gupta’s Multiple Chemical Sensitivity recovery program, I’d be putting the treatment to the test, up close and personal with a brush fire!

 

Just six days into Ashok Gupta's MCS recovery program, there was a brush fire less than a mile from my home. Had I not already learned the main amygdala retraining technique, there is no doubt that the smoke exposure would have initiated MCS symptoms. Instead, I was Gupta Girl in action! This photo was a blast to catch.

This post is part of a series about my experience doing Ashok Gupta’s “Advanced Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Fibromyalgia, and Multiple Chemical Sensitivity Recovery Programme,” which I started on September 30 and will last for at least six months.

On Oct. 6, I was ready to start Session 6 of Ashok Gupta’s Multiple Chemical Sensitivity recovery program, but first I wanted to review a concept already covered in a previous session: identifying patterns associated with my chemical sensitivity symptoms. This had proved challenging; I found it difficult to identify patterns that were so hard wired into me that I saw them as natural mechanisms rather than conditioning from the illness. The examples on the worksheet Gupta provides were all geared toward symptoms associated with Chronic Fatigue Syndrome and I couldn’t relate to any of it. So before starting Session 6, I sat down and focused on this task, determined to find my patterns before moving on to the next lesson.

The smoke got very thick very fast, sweeping through our gardens and house.

Suddenly, out of the blue, as I was sitting there trying to figure out my patterns, I got a whiff of smoke on the air—and in that instant of one breath, my whole body went into a state of alarm: ALERT! SMOKE! DANGER! My mind lurched, my heart raced, and I suddenly felt unsafe. In that moment, I learned firsthand about a main pattern: breathing something threatening causes an instant alarm in every part of my body; even before I have time to think or analyze the source of the problem, I feel unsafe. Bingo! A pattern.

I immediately started doing the main amygdala retraining technique using my brain, body and voice, just as Gupta taught me only two days prior. The smoke was getting really bad and I heard sirens in the distance, which played into my own internal alarm. My husband dashed off to find the source of the smoke, but in that moment, I chose to focus on the retraining technique rather than the fire. I did the technique three times in a row and the alarm inside me subsided. I experienced no MCS symptoms!

Meanwhile, my husband had discovered the smoke was coming from a brush fire less than a mile from our home. We then decided it was best to get out of the smoke so we grabbed some food and water and jumped in the car. I grabbed my camera on the way out the door.

What happened over the next hour was astonishing in regard to my chemical sensitivity. Had I not already learned the main amygdala retraining technique, there is no doubt that the smoke exposure would have initiated MCS symptoms. For years I’ve had problems breathing particulate matter. Exposure to yard waste fires, emissions from the island’s active volcano (called vog), or even heavy dust on the air can cause eye irritation, coughing and wheezing. Also, an exposure like that can make my chemical sensitivities to go into hyper drive. But none of that happened. No eye irritation, no coughing, no wheezing (and later, no ultra sensitivity to chemical exposures). In fact, I felt so good after doing the technique, that I wanted to get in the car and go get a closer look at the fire to see what was happening!

This is the view we had from up the slope looking down at all the excitement. A few minutes after we got to this vantage point, I realized we were standing in a just-planted corn field, probably recently sprayed with pesticides. I did a quick retraining technique just in case and then turned my attention back to taking photos. Our home is about a half mile to the left, right in the path of all that smoke.

We took a road going straight up the mountain behind our village to get out of the smoke and had a good vantage point to watch the fire. I had fun taking a lot of photos. Later, we drove down closer to where they were fighting the fire, and I had a super opportunity to photograph the helicopter as it brought water up from the ocean and dumped it on the flames! It was so exciting! (That’s the large photo at top of post.)

But even more exciting was that even though I was exposed to the smoke and several chemicals that previously would have gotten me very sick, I flew through that hour feeling on top of the world because I’d used Gupta’s amygdala retraining technique at the first sign of a pattern, which short circuited any MCS symptoms before they even started! (Remember that even though this retraining is happening in the brain, Gupta’s hypothesis does NOT hold that MCS is a psychological disorder. Gupta states emphatically that “MCS is a real physical disorder with real physical symptoms, and is not psychological in nature.”)

Here’s a list of a few things to which I was exposed during my fire adventure:

  • Heavy smoke from the brush fire.
  • Diesel exhaust.
  • Air freshener from a cop’s car that parked right next to me when I was photographing the helicopter.
  • Laundry products on a neighbor’s clothing. I actually hugged him without any problem at all.
  • The mail, which we picked up at the post office on the way home and included one package with new books and one package with new clothing, all of which I opened up and handled right away in the car before we got home.
  • Creosote on a wooden bridge when we took a back road home.

Previously, any one of those exposures would have made me feel ill. But I didn’t have a single MCS symptom!

I need to say here that not everyone with MCS will achieve these same quick results from the amygdala retraining technique. I’ve talked to people who say results from Gupta’s program happened very fast for them, too, but I’ve seen testimonials where people say it took six months or a year or more to see symptoms abate. Some people aren’t helped at all, although it’s been difficult for me to tell if they did everything as instructed for a full six months. But even with that possible variable, since no two cases of MCS are alike, it only makes sense that each person will have a different experience with the program.

If you decide to try this treatment, I think you should take Gupta’s advice and do it at your own pace, no rushing! Don’t worry about how fast it will work for you, just do everything Gupta teaches you at your own pace and keep at it for the full six months as he advises. Even though I am already seeing improvement in my chemical sensitivity, I still have tons of work to do and have fully committed to giving it my all for at least six months.

By the way, I slept soundly that night after the fire, no insomnia and none of the “buzzing” in my body that usually happens after a day of chemical exposures. I woke the next morning refreshed with no MCS “hangover,” which meant no time spent in a recovery phase of hours or days or weeks. Now that I had a full experiential understanding of a main pattern, I was now ready to do Session 6!

Gupta Girl

Disclaimer

 

This post is part of a series about my experience doing Ashok Gupta’s “Advanced Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Fibromyalgia, and Multiple Chemical Sensitivity Recovery Programme,” which I started on September 30 and will last for at least six months.

Ashok Gupta

Session 5 of Ashok Gupta’s recovery program, which I watched on Oct. 5, is a live demonstration of the main retraining technique where Gupta works with a patient who has Chronic Fatigue Syndrome (CFS). Because I had spent so much time learning the technique two days prior and was already seeing improvement in my chemical sensitivity symptoms, it was a lesson in patience for me to sit still and watch Gupta’s patient learn how to do it. But the section of this fifth session that I found the most interesting was the interview that Gupta conducted with the patient at the beginning of the session. It wasn’t the patient’s answers that caught my attention, but rather the questions Gupta was asking.

Especially interesting were the questions about what the patient was doing at the onset of the illness, how much stress he was under, whether or not he was actively engaged in ambitious activities and putting himself under a lot of pressure, asking a lot of himself and striving for perfection, go-go-go all the time—because guess what? According to Gupta, he finds that many of his patients were living that kind of lifestyle when they then experienced the particular stressor that initiated the illness. In the case of CFS, that stressor is often a particularly nasty and lengthy viral or bacterial infection, and in the case of MCS, it’s exposure to certain toxic chemicals (as we know through anecdotal evidence in our MCS community, there also are other stressors linked to the onset of MCS, for example exposure to toxic mold or ingestion of certain pharmaceuticals).

Martin Pall

Of course I’ve read a lot about severe psychological stress contributing to the onset of MCS, CFS and Fibromyalgia—see researcher Martin Pall’s website, scroll down to Table 1. But I found it fascinating that Gupta finds that everyday stressors of someone living an ambitious lifestyle also could set up that person for developing these illnesses. So understanding that better—the condition of a “perfect storm” of a stressful lifestyle (or as Martin Pall’s research has shown, severe psychological stress) coupled with exposure to the stressors associated with the illness—helped me understand better what needs to be done to initiate recovery from MCS and then, one step further, to sustain that healing. There may be, of course, other factors involved in MCS such as possible genetic predisposition, but the takeaway for me in this session is recognizing that a big part of Gupta’s treatment is about getting to the core causes of stress, stressors, and stress responses that contribute to the illness.

The other line of questioning I found interesting was about whether or not the patient’s mind is a busy mind that he can’t turn off and whether or not relaxation helps. As it turns out, a constantly busy mind may be a stress response related to the illness—not something consciously done but something hardwired into the brain and body through conditioning (remember that Gupta is not saying that MCS is psychological but that this conditioning is happening at physiological levels). For me, who thought that a busy mind that approaches life with a constant sense of urgency was a good and productive thing, the idea that a constantly busy mind is a stress response comes as a revolutionary concept. Never had it occurred to me that my busy mind was tied up with perpetuating and sustaining the chemical sensitivities and that it was pulling me farther and farther away from good health. But as I do Gupta’s main retraining technique and the other supplemental exercises to the point where I actually get that busy mind and over active sympathetic nervous system* switched off, the positive results are astonishing not only with the MCS symptoms abating but also in other unexpected ways as well. As it turns out, Gupta’s treatment is not limited to improving the acute illness at hand—it also has the potential of reaching deep down to my core to create an environment so that my body can heal itself of myriad stressors and imbalances.

Andrew Weil

Dr. Andrew Weil, the physician who diagnosed me with chemical sensitivity in 1995, writes in his book Sound Body Sound Mind, “Healing is making whole, restoring a state of perfection and balance that has been lost through illness or injury… I’ve learned that you are your own physician and have to heal yourself. The trick is to get your ego out of the way, get your concepts out of the way, and just let the body heal itself. It knows how to do it.”

The Gupta Programme is teaching me how to do that—how to get my ego out of the way, get my concepts out of the way—so that my body has a chance at recovering from Multiple Chemical Sensitivity.

More soon!

Gupta Girl

Disclaimer

*I had originally written “central nervous system,” but have corrected it to “sympathetic nervous system.”

 

This post is the third in a series about my experience doing Ashok Gupta’s “Advanced Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Fibromyalgia, and Multiple Chemical Sensitivity Recovery Programme,” which I started on September 30 and will last for at least six months.

I watched Session 2 on Saturday, October 1. I watched this whole session on the DVD but I’m going to refer you back to the first post in my blog series about my doing the program, because this actual Session 2 on the DVD is geared to ME/CFS, not MCS.

Basically, you can read about Gupta’s basic hypothesis on his website (his peer reviewed and published hypothesis was originally developed for his own case of Chronic Fatigue Syndrome and has now been expanded to include other related illnesses such as MCS). Then you can read about his hypothesis in relation to MCS. It’s dense reading but I highly recommend you make an effort to read it, that is if you really want to understand what the program is addressing.

A summary of key points in Session 2 on the DVD include this (quotation from the transcript):

  • we have a conscious mind and a subconscious mind
  • inside the subconscious mind there is a brain structure called the amygdala (small almond shaped structure in what is called the limbic system of the brain, and in fact there are two of them)
  • the amygdala’s role is to decide if something threatens us, and to release an appropriate response to protect us, often involving the fight or flight response
  • the fight or flight response is also known as the stress response, or stimulation of the sympathetic nervous system
  • we can sometimes unknowingly train the amygdala to be concerned or even fearful of things that we don’t want to be afraid of (emphasis added)
  • through our conscious mind, we can always retrain the amygdala

I know that list poked a few of you with a stick– I know! I felt poked, too! Some of you are thinking, “Is he saying it’s all in my mind??” No, he’s not. Don’t miss the key word in the list above: “unknowingly.” Gupta’s hypothesis does NOT hold that MCS is a psychological disorder. Gupta states emphatically that “MCS is a real physical disorder with real physical symptoms, and is not psychological in nature.” So my best advice at this stage in the game is, at least for the moment, to suspend any disbelief you may have, let go of any cynicism, try to do the “homework” I suggested, and just come along with me for the ride, keep me company on my journey. And don’t lose sight of that last bullet point: “through our conscious mind, we can always retrain the amygdala”– because, ultimately, THAT is where we are going!

As I blogged in my first post in the series, Gupta recently released a video about his hypothesis in relation to MCS. Be sure to take the time to watch this, it’s important! Here’s the blurb and video:

Multiple Chemical Sensitivities can be explained by a new hypothesis implicating the limbic system of the brain, specifically the amygdala. The brain structure called the insula is also involved. The Gupta Programme, or Gupta Amygdala Retraining is a brand new treatment for MCS, ME/CFS & Fibromyalgia which retrains the brain to stop it reacting to chemicals and electrical stimuli. This video is part of a coaching programme on the treatment specifically dealing with MCS.

More soon!

Gupta Girl

Disclaimer

 

This post is the second in a series about my experience doing the Gupta Amygdala Retraining program, which I started on September 30 and will last for at least six months.

The Gupta Amygdala Retraining packet contains a12-DVD set of Gupta's lessons with the retraining techniques and supporting exercises. There is a book that's basically the transcript of the lessons on the DVDs (at left). The packet also contains audio CDs with supplemental exercises. In addition, the packet contains the "Mind Map," the large poster you see folded up with the copyright symbol. The Mind Map is a colorfully bold graphic of the seven steps of the main retraining technique. You lay it on the floor, it reminds me of the game Twister. It's is the most ingenious teaching tool for showing you how to engage your body, mind, and voice in the very specialized main brain retraining technique!

The Gupta Amygdala Retraining packet arrived from Ashok Gupta’s clinic in London on September 30 and I was excited to get started! I’d been inspired to give the program a try by testimonials from members of Our Canary Report Community: Debbie (Part One and Part Two) and Erik (first post and second post on his progress). Recently, Els, who lives in Denmark and wrote a book about Multiple Chemical Sensitivity a couple of years ago, published her testimonial– it’s so well done that Gupta has added a link to it on his own website. These are three people that I have communicated with over the past three years and have found each one to be thoughtful, intelligent, and up-to-date on current research about MCS. I know each of them to have a good head on their shoulders and keen analytic skills, so my ears perked up when I started to see consistency between their stories of recovery from MCS through Gupta’s treatment.

But when choosing medical treatments or procedures, testimonials are never enough for me no matter the source. I need to see strong credentials from the people I choose as part of my health team. Though not a medical doctor, Ashok Gupta brings some heft to his hypothesis and treatment:

  • Gupta had Chronic Fatigue Syndrome himself as a student at Cambridge over 10 years ago and completely healed himself through experimenting with the techniques he’s now honed into his amygdala retraining program. (Please note that current peer-reviewed research shows that CFS/ME, MCS, Fibromyalgia, and Post Traumatic Stress Disorder are all part of the same family of illnesses; see the published work of biochemist Martin Pall.)
  • Gupta has worked successfully with CFS patients for seven years at his clinic in London.
  • His hypothesis is published in a peer reviewed medical journal.
  • He has conducted an audit on the success rate of his treatment, also peer reviewed and published.
  • He has strong working knowledge and experience in Neuro-Linguistic Programming (a basic component of the main retraining technique in the Gupta treatment).
  • He’s done his own research into recent advances in brain neurology, notably the work of Joseph Ledoux.
  • He understands Martin Pall’s theory about CFS/ME, MCS, Fibromyalgia and PTSD, and has worked Pall’s findings into his own hypothesis and model; if you look at Gupta’s graphic about his hypothesis (scroll down to the dark blue graphic titled “The Amygdala Hypothesis”), you’ll see “nitric oxide increase” as a secondary illness cycle– the NO/ONOO- theory is Pall’s contribution to the current literature on MCS. This inclusion of Pall’s findings into Gupta’s model made a great impression on me because it showed me Gupta is not only knowledgeable about current MCS research, but he incorporated and improved upon that research through his own hypothesis and model.

I was very excited when the packet arrived! September 30 was a Friday, and as soon as I finished my work for my day job at about 4:30p, I opened up the packet and reviewed the contents. The packet contains the main 12-DVD set of Gupta’s lessons with tons of background information and the retraining techniques and supporting exercises. There is a book that’s basically the transcript of the lessons on the DVDs (I curl up on the couch with a cuppa and that book a lot!). The packet also contains a couple of audio CDs with supplemental exercises.

In addition, the packet contains the “Mind Map,” a large, colorfully bold graphic of the seven steps of the main retraining technique. You lay it on the floor, it reminds me of the game Twister.  It’s is the most ingenious teaching tool for showing you how to engage your body, mind, and voice in the very specialized main brain retraining technique! I can’t wait to tell you about learning the main retraining technique in a future post (Session 4).

Gupta has made the first session available on YouTube, so you can watch the whole thing below! In my journal, my main takeaways from this session are:

  • Gupta believes MCS is a real physical condition with real physical symptoms in the body.
  • The body’s ability to heal is very much based on the state of mind during healing. (This comes into play when learning the main retraining technique and supplemental exercises.)
  • Make a commitment to do the program for six months. Done!
  • Ups and downs are expected, just focus on the long term goal of health.
  • Laugh out loud as much as possible!
  • Get out of the house as much as possible, take long walks in nature, get as much daylight and fresh air as possible.
  • Do only one session a day.

So here you go, Session 1 of Gupta’s Amygdala Retraining program (all you have to do is replace “CFS” with “MCS” and you are good to go for applying the lessons to MCS):

Session 1, Part 1:

Session 1, Part 2:

Session 1, Part 3:

Session 1, Part 4:

Session 1, Part 5:

Session 1, Part 6:

More Soon!

Gupta Girl

Disclaimer

 

This post is the first in a series about my experience doing the Gupta Amygdala Retraining program, which I started on September 30 and will last for at least six months.

Ashok Gupta

I’m going to cut to the chase because I know the question you are all asking: Is the Gupta Amygdala Retraining program working for me? Even though I started the program less than three weeks ago, I can already answer that question with a resounding YES! On the very day that I learned how to do the main brain retraining technique (Session 4 of the 12-DVD program), I experienced a dramatic improvement in my Multiple Chemical Sensitivity and in my overall health. It was, and continues to be, nothing short of an astonishing experience and I look forward to sharing it with you.

I’m going to post dispatches here about the experience of going through the program, but first, for those of you who have not yet explored the Gupta Programme, here is some homework for you so you understand what I’m doing.

First, it’s important that you understand Ashok Gupta’s hypothesis about the cause of Multiple Chemical Sensitivity and related illnesses like Chronic Fatigue Syndrome and Fibromylagia. You can read about his basic hypothesis, which was originally developed for Gupta’s own case of Chronic Fatigue Syndrome and has now been expanded to include other related illnesses such as MCS. Then you can read about his hypothesis in relation to MCS.

Here’s a video about Gupta’s hypothesis in relation to MCS (by the way he was originally going to charge for this video, and then just decided to put it up on YouTube for everyone’s access). Here’s the vid’s blurb:

Multiple Chemical Sensitivities can be explained by a new hypothesis implicating the limbic system of the brain, specifically the amygdala. The brain structure called the insula is also involved. The Gupta Programme, or Gupta Amygdala Retraining is a brand new treatment for MCS, ME/CFS & Fibromyalgia which retrains the brain to stop it reacting to chemicals and electrical stimuli. This video is part of a coaching programme on the treatment specifically dealing with MCS.

Couple notes I just want to mention. It’s as important to understand what the treatment IS NOT as it is to understand what it IS:

  • The main brain retraining techniques are NOT meditation or creative visualization or positive thinking, they are highly specialized, repetitive techniques you do yourself with both your body and your brain that literally retrain your brain so you can recover from the illness.
  • The main brain retraining techniques are NOT treatments for a psychological disorder, they are treatments for a physical illness. Gupta states over and over and over again that “MCS is a real physical disorder with real physical symptoms, and is not psychological in nature.” The main brain retraining techniques are addressing that physical disorder.

More soon!

Gupta Girl

Disclaimer

 

Our Canary Report network will be offline for six months to a year and will not be accessible to our members; this blog will remain online and you will still be able to access all pages and information posted here during the entire hiatus of the network.

Aloha to Our Canary Report Community,

Greetings to you all.

This message is to inform you that as of today, I will be taking a leave of absence from Our Canary Report network for six months to a year. During this time, the network will be offline and will not be accessible to our members—however, you will have the next seven days to explore our archives, retrieve and save information, swap email addresses with your friends, and any other activity you need to do before the network is taken offline on October 10.

This blog The Canary Report will remain online and you will still be able to access all pages and information posted here during the entire hiatus of the network.

During my leave, I will be undertaking Multiple Chemical Sensitivity “field work” by doing the Gupta Amygdala Retraining program. Think of me as your intrepid reporter investigating an experimental treatment that I believe may hold great potential of helping people with MCS regain health and well being. I will be journaling during my experience and it is my intent to report back to you about my journey and about the efficacy of the treatment.

I have loved our work together over the past three years, supporting and inspiring each other. I am going to miss you all very much. It is my intent to re-open the network again after I complete the amygdala retraining program in six months to a year, so until we meet again, I wish you all the best.

Aloha for now,

Susie

 

Resources and information about the peer-reviewed MCS research of biochemist Martin Pall, PhD.

Profile photo of Martin Pall

MCS researcher Martin Pall, PhD

Martin Pall’s research, a review of more than 1,500 references to scientific literature, shows a common causal (etiologic) mechanism for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Multiple Chemical Sensitivity, Fibromyalgia and Post-Traumatic Stress Disorder: The chronic nature of MCS and also related multisystem illnesses is thought to be produced by a biochemical vicious cycle mechanism, the NO/ONOO- cycle, which is initiated by various stressors that increase nitric oxide and peroxynitrite levels (with some but not others acting via NMDA stimulation).

Click here for a one-page description of Pall’s theory as presented in his book Explaining ‘Unexplained Illnesses’: Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Posttraumatic Stress Disorder, Gulf War Syndrome and Others (2007).

Contact info:
Martin L. Pall, professor emeritus of biochemistry and basic medical sciences, Washington State University.
Research director, Tenth Paradigm Research Group.
Website: www.thetenthparadigm.org
martin_pall@wsu.edu
503.232.3883

Martin Pall explaining elevated nitric oxide and oxidative stress in Multiple Chemical Sensitivity and related illnesses (three-part video, posted 2010):

Part One

Part Two

Part Three

ABSTRACT on Pall’s MCS research, published as chapter 92 in the prestigious reference work for professional toxicologists,  General and Applied Toxicology, 3rd Edition (2009, John Wiley & Sons):

Cases of multiple chemical sensitivity (MCS) are reported to be initiated by seven classes of chemicals. Each of the seven acts along a specific pathway, indirectly producing increases in NMDA activity in the mammalian body. Members of each of these seven classes have their toxicant responses lowered by NMDA antagonists, showing that the NMDA response is important for the toxic actions of these chemicals. The role of these chemicals acting as toxicants, in initiating cases of MCS has been confirmed by genetic evidence showing that six genes that influence the metabolism of these chemicals, all influence susceptibility to MCS. It is likely that chemicals act along these same pathways, leading to increased NMDA activity when they trigger sensitivity responses in MCS patients.

The chronic nature of MCS and also related multisystem illnesses is thought to be produced by a biochemical vicious cycle mechanism, the NO/ONOO- cycle, which is initiated by various stressors that increase nitric oxide and peroxynitrite levels (with some but not others acting via NMDA stimulation). The NO/ONOO- cycle is based on well documented individual mechanisms. The interaction of this cycle with previously documented MCS mechanisms, notably neural sensitization and neurogenic inflammation, explains many of the previously unexplained properties of MCS. This overall mechanism is also supported by physiological correlates found in MCS and related multisystem illnesses, objectively measurable responses to low level chemical exposure in MCS patients, many studies of apparent animal models of MCS and also evidence from therapeutic trials of MCS-related illnesses. Some have argued that MCS is a psychogenic illness, but this view is completely inconsistent with this diverse data on MCS and related illnesses and the literature claiming psychogenesis of MCS is deeply flawed. In addition, two rare predictions that can be used to test psychogenesis both lead to rejection of the psychogenic hypothesis. While the NO/ONOO- cycle mechanism for MCS is supported by many different observations, there are also multiple areas where further study is needed.

To learn more, see this article by Martin Pall in the Townsend Letter: How Can We Cure NO/ONOO− Cycle Diseases? Approaches to Curing Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Fibromyalgia, Multiple Chemical Sensitivity, Gulf War Syndrome and Possibly Many Others (2010). ABSTRACT:

The NO/ONOO− cycle is a biochemical vicious cycle that is thought to cause such diseases as chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), multiple chemical sensitivity (MCS), fibromyalgia (FM), and possibly a large number of other chronic inflammatory diseases. The chemistry/biochemistry of the cycle predicts that the primary mechanism is local such the depending on where it is localized in the body, it may cause a variety of different diseases. Previous studies have shown that agents that lower such cycle elements as oxidative stress, nitric oxide, inflammatory responses, mitochondrial dysfunction, tetrahydrobiopterin (BH4) depletion and NMDA activity produce clinical improvements in CFS/ME and FM patients, consistent with the predictions of the cycle mechanism. Multiagent protocols lowering several aspects of the cycle appear to be the most promising approaches to therapy. These include an entirely over-the-counter nutritional support protocol developed by the author in conjunction with the Allergy Research Group. However, such mulitagent protocols to date have not produced any substantial numbers of cures of these presumed NO/ONOO− cycle disease. Why is that? This paper argues that what is called the central couplet of the cycle, the reciprocal relation between peroxynitrite elevation and BH4 depletion, is not being adequately downregulated by these multiagent protocols. Ten agents/classes of agents are available, each of which downregulates one or the other end of this central couplet. It is suggested, then, that treatments that simultaneously effectively downregulate both ends to the central couplet, when used along with multiagent protocols lowering other aspects of the cycle and avoidance of stressors that otherwise upregulate the cycle, will lead to substantial numbers of cures of these chronic diseases.

Interview: A conversation with MCS researcher Martin Pall, PhD (2005) by Linda Powers, CBS Interactive Business Network.

Article on Martin Pall, PhD: The NO/ONOO- Oxidative-Inflammatory Disease Model (2007).

An informational flyer about Pall Protocol Antioxidant Suggestions. You can find the supplements at the Allergy Research Group, but most of them are less expensive at ProHealth. (The Canary Report/Susie has no financial interest in either company.)

Articles and interviews with Martin Pall at ProHealth.com:

Radio interview with Martin Pall on WOR Willner Window (2009).

More posts at The Canary Report about Martin Pall’s research.

The above links are posted for informational purposes only. The Canary Report is not responsible for the content of external websites, and the listing does not infer endorsement. Please note that Martin Pall is not a medical doctor and is clear in his writings that MCS symptoms and remedies differ from patient to patient because the tissues impacted differ from one patient to another; he emphasizes that none of his writings are to be taken as medical advice. Check with your doctor before making any change in your supplement regime.

 

Martin Holladay, a former plumbing wholesaler, now senior editor at GreenBuildingAdvisor.com and a builder by trade, writes an article this week entitled Helping People with Multiple Chemical Sensitivity where he takes a stab at defining MCS.

Martin Holladay

Martin Holladay

Black and Temple explain that in 1996, attendees at a World Health Organization conference in Berlin proposed that the term “idiopathic environmental intolerance” (IEI) be substituted for the collection of symptoms formerly referred to as “multiple chemical sensitivity.” (“Idiopathic” means “of unknown cause.”) Black and Temple note that idiopathic environmental intolerance “is a subjective illness marked by recurrent, nonspecific symptoms attributed to low levels of chemical, biologic, or physical agents. These symptoms occur in the absence of consistent objective diagnostic physical findings or laboratory tests that define an illness. Many experiments and observational studies consistently identify psychopathology in patients with IEI, and implicate behavioral or psychiatric causes for this illness. This indicates that the underlying illness in many cases of IEI is actually a psychiatric disorder, such as a somatoform, depressive, or anxiety disorder.”

General and Applied Toxicology

I find myself wondering why on Earth is a builder writing an article about the medical aspects of MCS? He was doomed to miss the hundreds of current studies supporting a physiological basis for chemical sensitivity. This document lists over 100 citations for peer-reviewed journal articles that support a physiological basis for MCS, and the 11-year review of the MCS literature by biochemist Martin Pall showing a physiological mechanism for the illness is now published in the prestigious international manual for toxicologists General and Applied Toxicology, 3rd Edition. By the way, Martin Pall does a great job destroying the “psychopathology” argument in this post.

While I appreciate Mr Holladay’s interest in the use of nontoxic building materials in homes for people with MCS,  he ought to stick with his own area of expertise and leave the medical analysis on MCS to those who keep up with the current research. His article does more far more harm than good to the MCS community.

 

When you have MCS and you are exposed to certain toxic chemical agents, a series of symptoms are initiated automatically like irritation of the respiratory tract, tachycardia, headaches, mental confusion, dizziness, nausea, extreme fatigue or pain. These symptoms don’t get better until you cease contact with the chemical agent that produced it. The symptoms can last days or even weeks.

Eva Caballé

Eva Caballé

By contributor Eva Caballé, Spain.

What is Multiple Chemical Sensitivity?

Multiple Chemical Sensitivity (MCS) is an acquired chronic illness, not a psychological one, which manifests itself with multisystemic symptoms as a reaction to a very small exposure to chemical products, normal everyday chemicals but unnecessary ones, like perfumes, air fresheners or laundry softeners.

The symptoms, which are chronic and they become acute in a crisis, include fatigue and respiratory, digestive, cardiovascular, dermatological and neurological problems.

MCS is a syndrome with four grades of severity, so not all of us who are sick suffer the same level of disability and isolation.

It is important to note that MCS is not an allergy.

It is an illness which has been known since the 1950s, but it has yet to be recognized by the World Health Organization (WHO), despite that there are more than 100 research articles that support the organic basis of MCS, that the number of people affected is increasing rapidly, at a younger age, and that the European Parliament includes MCS in the growing number of illnesses related to environmental factors. MCS has already recognized as a physical disease in Germany, Austria and Japan.

What percentage of the population has MCS?

There are no studies in Spain, but it is thought to be affected between 0.5% and 12% of the general population, according to the grade.

In countries where there are statistics about this illness, we see that the amount of people that have MCS is not small. According to the Environmental Health Association of Quebec, 2.4% of Canadians have MCS. According to Professor Martin L. Pall, PhD, the prevalence of severe MCS in the U.S is approximately 3.5% of the population.

So MCS is not a “rare disease,” which are the ones that affect less than 0.05% of the population. MCS is an emerging and hidden disease.

Chemical products are toxic and they affect us all. Chemical products are linked to illness like cancer, asthma, allergies, autoimmune diseases or any other illness of environmental origin.

How can you know that you are developing MCS?

The most common symptom is to notice unbearable chemicals which one did not notice before. One stops tolerating various chemical agents like cleaning products, perfumes, tobacco smoke, car emissions, air fresheners, etc.

You also may stop tolerating alcohol, dairy products or gluten. You also may develop intolerance to various foods and medications.

Often there are other environmental intolerances: to heat, to cold, to noise, to vibrations, to sunlight and to electromagnetic fields (computers, high power lines, telephones, cellular phone antennas, microwaves, etc).

MCS entails the loss of tolerance of chemical products in susceptible persons and there are two ways of developing MCS: from one single exposure to toxics at a high dose (fumigation, for example) or by many exposures to small amounts over the years. In the second group there are an increasing number of people with CFS/ME and FMS who, with the years, also develop MCS.

How is MCS diagnosed?

The diagnosis is clinical, based on the symptoms. There are no tests to diagnose MCS and other medical conditions must first be ruled out.

For the diagnosis, doctors use the questionnaire QEESI (Quick Environmental Exposure and Sensitivity Inventory) which is a sensitive and fast questionnaire instrument with five scales used to evaluate a person’s level of chemical sensitivity or intolerance.

6 consensus criteria for the definition of MCS:

  1. A chronic condition.
  2. Symptoms recur reproducibly.
  3. Symptoms recur in response to low levels of chemical exposure.
  4. Symptoms occur when exposed to multiple unrelated chemicals.
  5. Symptoms improve or resolve when trigger chemicals are removed.
  6. Multiple organ systems are affected.

When you have MCS and you are exposed to certain toxic chemical agents, a series of symptoms are initiated automatically like choking, irritation of the respiratory tract, tachycardia, headaches, mental confusion, dizziness, nausea, diarrhea, extreme fatigue and/or pain. These symptoms don’t get better until you stop being in contact with the chemical agent that produced it. The symptoms can last days or even weeks.

How is MCS treated?

Because of the pathophysiological bases of this syndrome are still unknown, there is no specific treatment for MCS. But there are a lot of treatments that help to control MCS and improve our health (sauna, supplements, homeopathy, etc.), and it’s very important to find a specialized doctor who studies our case, because each patient is different, depending on the genetic, the associated pathologies and the MCS grade.

Besides the treatment, is very important to put into practice the Environmental Control. Environmental Control is to basically avoid, as much as possible, any exposure to toxics or chemical substances. But in spite of this, MCS is chronic and persistent and it can reduce the quality of life of the sufferers.

Environmental Control is to avoid the chemicals or foods that may trigger reactions, avoid humid environments and avoid environments that could cause irritation (smoke, gas).  This requires that we substitute all beauty and cleaning products with ecological ones without aroma; eat organic and non-processed foods (eliminate those we don’t tolerate) cooked using non-toxic cookware; filter the drinking water and also the water for cooking and showering; use a carbon-filter mask in situations in which there are a high concentration of toxics; get an air purifier; use ecological clothing with organic fabrics and organic dyes; avoid or minimize exposure to electromagnetic fields and in general remove everything that that we don’t tolerate (furniture, clothing, cosmetics, etc.).  Sometimes is even necessary to change our residence. The Environmental Control benefits the MCS sufferer and also his entire family and it’s recommended for people with allergies or asthma in other countries. It’s also recommended for people with Chronic Fatigue Syndrome and Fibromyalgia.

Environmental Control: basic guidelines and tips (in Spanish).

Scientific evidence

In September 2008, was published the study “Is multiple chemical sensitivity a learned response? A critical evaluation of provocation studies” by Goudsmit and Howes at Journal of Nutritional & Environmental Medicine, which concluded that MCS is related to chemicals and it’s not a psychological illness.

In May 2009, Professor Anne C. Steinemann and Amy L. Davis of the University of Washington published a compilation of research on MCS with more than 100 peer-reviewed journal articles that support a physiological basis for MCS.

After that compilation, 2 important studies have been published:

In October 2009, the Journal of the Neurological Sciences published the study “Brain dysfunction in multiple chemical sensitivity” done by the Department Of Pulmonology of the Hospital Vall Hebron of Barcelona (Spain).

And at the end of April 2010 has been published the study “Biological definition of multiple chemical sensitivity from redox state and cytokine profiling and not from polymorphisms of xenobiotic-metabolizing enzymes” done by the IDI Institute of Rome (Italy) at the Toxicology and Applied Pharmacology – Elsevier.

Also last year, General and Applied Toxicology, 3rd Edition, published a chapter on MCS done by Researcher Martin Pall, PhD entitled “Multiple Chemical Sensitivity: Toxicological Questions and Mechanisms.”

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Eva Caballé is an economist from Barcelona, Spain, author of the book Desaparecida: Una vida rota por la Sensibilidad Química Múltiple (Missing: A life broken by Multiple Chemical Sensitivity) published in Spanish by El Viejo Topo, Barcelona, Spain, 2009. She authors NO FUN, a Spanish blog with an English section about Multiple Chemical Sensitivity, Chronic Fatigue Syndrome and Fibromyalgia, with information and advice for people who are sick or who want to live a healthier life free of toxics. She is a regular contributor at The Canary Report and at the art magazine Delirio (Delirium).

 

AUSTRALIA: The controversial and troubled report on “A Scientific Review of Multiple Chemical Sensitivity: Identifying Key Research Needs” has finally been released.

By contributor Harry Clark, President, MCS Society of Australia, Inc.

Australian flag

The flag of Australia.

Harry Clark

Harry Clark

 

Hot off the press! The controversial and troubled review on “A Scientific Review of Multiple Chemical Sensitivity: Identifying Key Research Needs” has finally been released.  I’ll be reading it over the next few days.

Reading the submissions made to the report is a worthwhile and illuminating exercise. Dr Colin Little, who sees people with Multiple Chemical Sensitivity in Victoria, has made a submission, as has biochemist and MCS researcher Prof Martin Pall, WA Greens Hon Giz Watson, some MCS organisations, individuals, SA Health and so on (and my submission via MCS Society of Australia is there too).

Happy reading!

Below is the broadcast notification from Australia’s National Industrial Chemicals Notification and Assessment Scheme (NICNAS):

I am pleased to inform you that the joint National Industrial Chemicals Notification and Assessment Scheme (NICNAS) and the Office of Chemical Safety and Environmental Health’s (OCSEH) final report titled “A Scientific Review of Multiple Chemical Sensitivity: Identifying Key Research Needs” is now available from the NICNAS website at http://www.nicnas.gov.au/Current_Issues/MCS.asp

NICNAS/OCSEH released the draft report for comment in February 2010 and NICNAS contacted all who submitted comments to the draft report on Multiple Chemical Sensitivity (MCS) requesting permission to place submissions on the NICNAS website. The submissions to the draft MCS report are also now available. These can be accessed from the NICNAS website at http://www.nicnas.gov.au/Current_Issues/MCS.asp

All submissions have been considered in the revision of the draft MCS report, regardless of publication, or otherwise, on the NICNAS website.

A hardcopy of the report is currently being developed and will be available shortly. If you would like to receive a hardcopy of the report please do not hesitate to contact myself on the details below.

Kind Regards,

Julie Brown
Admin Assistant
NICNAS – National Industrial Chemicals Notification and Assessment Scheme
Australian Government Department of Health and Ageing

T + 61 2 8577 8870
F + 61 2 8577 8888
E julie.brown@nicnas.gov.au

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