Study shows effectiveness of researcher Martin Pall’s approach to Multiple Chemical Sensitivity

Posted on Jan 06, 2010 by Susie Collins in Blog, MCS, Research, Susie Collins

A new pilot study from The Institute for Functional Medicine Clinic in Falun, Sweden, demonstrates the effectiveness of Martin Pall’s approach to explaining the causes of Multiple Chemical Sensitivity.

The Allergy Research Group reports new research supports Martin Pall’s hypothesis about the cause of MCS.

The group’s newsletter dedicates three articles to the discussion:

“New Research Confirms Martin Pall Hypothesis: Pilot Study With Free-Radical Reducing Supplements Improves Treatment-Resistant CFS,” an interview with Ingrid Franzon, N.M. M.S.c.
“Evaluation of Quality of Life in Persons with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Before and After Administration of Food Supplements Designed to Reduce Free Radical Activity,” by Ingrid Franzon, MSc, Bo Jonsson M.D., Ph.D., and Peter Wilhelmsson, N.D.
“NO/ONOO: A Brief Summary of the Work of Martin Pall, Ph.D.”

Pall has assembled an impressive body of data to demonstrate that elevated levels of nitric oxide (NO) and its highly damaging metabolite, peroxynitrite (ONOO-), are at the crux of a runaway cycle of free-radical damage in which inflammatory molecules are chronically elevated, damaging the immune and nervous systems. Peroxynitrite initiates a complex biochemical vicious cycle, known as the NO/ONOO- cycle, which is responsible for multiple chemical sensitivity, chronic fatigue syndrome, fibromyalgia, Gulf War syndrome and post-traumatic stress disorder. The basic concept here is actually quite simple. Stressors act mainly through peroxynitrite-derived free radicals to initiate the cycle and once the cycle is initiated it is the cause of continuing illness.

By correcting the high levels of NO and ONOO- with a range of natural antioxidants, a puzzling array of symptoms can be ameliorated and sometimes the illness itself can be completely reversed. (See Allergy Research Group® Newsletter Focus, July 2007.)

Pall suffered from severe chronic fatigue syndrom (CFS) and multiple chemical sensitivy (MCS) for 18 months, and cured himself, then set about dedicating his career to investigating the cause of these disabling conditions. Now his approach has started to garner widespread attention, with publication of an entire chapter by Pall in the upcoming General and Applied Toxicology, 3rd edition by (editors TK), published by John Wiley, Inc. In addition, a new pilot study from The Institute for Functional Medicine Clinic in Falun, Sweden demonstrates the effectiveness of this approach. Pall also has a forthcoming article on CFS in Current Opinion in Psychiatry.

As Pall points out, the acute stressor(s) that lead to CFS and MCS and the other mystery illnesses range from infections to toxic exposures to physical or mental trauma. But no matter what the initiating cause, the downstream effect is free radical damage mediated by raised levels of NO and ONOO-.

I believe Martin Pall is at the leading edge of MCS research, and I encourage you to explore his hypothesis as well as his supplement protocol. I think we will start to see more and more research supporting his approach.

As with all approaches to MCS, what applies to one person with MCS may not apply to another. Always approach MCS therapies and protocols keeping this in mind: MCS symptoms and remedies differ from patient to patient because the tissues impacted differ from one patient to another. Proceed with caution, preferably under an environmental physician’s care and guidance.

You can learn more about Pall’s research and protocol on his website The Tenth Paradigm.

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Tags: MCS, Multiple Chemical Sensitivity, Research

12 Responses to “Study shows effectiveness of researcher Martin Pall’s approach to Multiple Chemical Sensitivity”

Donovan Banerjee

06. Jan, 2010

Very glad to see this! I have been doing a great deal of reading about this protocol myself. It would be thrilling to see both more research supporting his hypothesis, and more success in managing MCS, which would free so many from such a devastating illness.

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Susie Collins

07. Jan, 2010

Aloha Donovan, I’m fascinated with Martin Pall’s research. A member of our network is researching whether or not the Swedish study is published in a journal. We will keep you posted. Aloha, Susie

Reply to this comment
Harry

07. Jan, 2010

this is a great new year gift. I also think Pall is the leading researcher and thinker on MCS at this time.

Reply to this comment
- Susie Collins
  
  23. Jan, 2010
  
  I do too, Harry. Pall’s been incredibly thorough in reviewing the literature, and it’s based on solid animal studies. To see his work recognized by peers in toxicology is very exciting.
  
  Reply to this comment
Lucy and amy

21. Jan, 2010

I hope this is one step closer to validation and acceptance by the FDA and the AMA.

This is the main reason I am being denied ALL medicaL care for any chemical exposures. NO FDA approved treatment.

Its unethical to allow people to get sicker due to red tape.

Dr Pall IS changing this !

Reply to this comment
- Susie Collins
  
  23. Jan, 2010
  
  Aloha Amy, it’s great that all of Pall’s protocol is available over the counter, although must be paid for out-of-pocket. I do believe his work is getting us closer to recognition, but it’s still a long way off unfortunately.
  
  Reply to this comment
Catherine H.

23. Jan, 2010

I am on Martin Pall’s protocol and it has made such a BIG difference in my day-to-day life. I know he has it right and I am very, very angry that although I am fully insured (assuming Medicare and Medicaid are good insurance plans…sure they are??) I have to pay out of pocket to get the nutriceuticals therapy. Medicare Part D won’t pay for this as Congress made it a law forbidding Medicare to pay for vitamins and minerals…even though this protocol is through a RX by a licenced doc and an accredited pharmacy! Shameful to withold medicine from people this ill.

I believe Martin Pall will one day receive a Nobel prize for medicine! For all of us, let’s hope so.

Reply to this comment
- Susie Collins
  
  23. Jan, 2010
  
  Aloha Catherine, thanks much for your feedback on the Pall Protocol, I’m so happy about you feeling better! Big Pharma has a stranglehold on insurance, let’s hope that changes sometime soon. It is fascinating to see that Pall’s research not only gives an explanation about MCS and related illnesses, but also posits a whole new disease paradigm– and that indeed is the stuff of Noble prizes.
  
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Matthew Hogg

23. Jan, 2010

I also agree Martin Pall is perhaps the leading light in MCS research and his work is very thorough (not to mention he’s a really nice guy!). If this pilot study is validated by large scale placebo controlled trials then it will be incredible news for canaries everywhere.

I would temper this with the fact that the body is so complex and the mechanisms of disease so complex that no one person has all the answers, no matter how intelligent – meaning researchers tend to latch onto one aspect and focus on this – often missing the bigger picture. I hope this doesn’t turn out to be the case with NO and peroxynitrite.

Regarding the quotes from ARG – I always find it amusing when people are described as having had “severe” CFS and/or MCS for periods of time as short as “18 months”. And that you can be “cured” of these diseases when their etiology remains unknown is inaccurate at best!

Reply to this comment
Beebs

30. Jan, 2010

Which site can I find Dr Pall’s Protocol? I couldn’t find it on the yahoo Tenth Paradigm group. Thanks

From what I read, Dr Pall’s research is sound.

Reply to this comment
Susie Collins

30. Jan, 2010

Aloha Beebs, your blog is very interesting but heartbreaking, too. I’m sorry to see you have so many serious health issues.

Here’s the link to Martin Pall’s website http://thetenthparadigm.org/index.html

Here’s his explanation of the approaches to therapy http://thetenthparadigm.org/arg.htm

Here’s the link to the protocol http://thetenthparadigm.org/arg.htm

I find Pall’s research sound, too, and I hope you’ll keep us posted on your discoveries.

Take care and stay in touch,
Susie

Reply to this comment
Beebs

31. Jan, 2010

Hi Susie

Many thanks for the all info you provided. I am sorry that you too have health issues.

I am looking at various protocols, but many include ALA, Fish OIls, NAC, and so does Dr Pall’s , yuk. There might be a way of substituting these. I did find a product which contains EPA/DHA, sourced from sea algues which could be substituted for Fish OIls. I am looking for substitutes for ALA & NAC, but difficult task, yuk …

It’s comforting to read of some improving on Dr Pall’s protocol.

I am also reading about the liver, and its various pathways. Little is known about its complex mechanism. Hopeful and looking for alleviations of symptoms. Quite a task,

Wishing you well.

Beebs

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